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INSTRUCTIONS

Take Zanaflex exactly as prescribed by your doctor.

A single dose of 8 mg of Tizanidine reduces muscle tone in patients with spasticity for a period of several hours. The effect peaks at approximately 1 to 2 hours and dissipates between 3 to 6 hours. Effects are dose-related.

Although single doses of less than 8 mg have not been demonstrated to be effective in controlled clinical studies, the dose-related nature of tizanidine's common adverse events make it prudent to begin treatment with single oral doses of 4 mg. Increase the dose gradually (2 to 4 mg steps) to optimum effect (satisfactory reduction of muscle tone at a tolerated dose).

The dose can be repeated at 6 to 8 hour intervals, as needed, to a maximum of three doses in 24 hours. The total daily dose should not exceed 36 mg.

Experience with single doses exceeding 8 mg and daily doses exceeding 24 mg is limited There is essentially no experience with repeated, single, daytime doses greater than 12 mg or total daily doses greater than 36 mg.

Ask your health care provider any questions you may have about how to use Zanaflex.

STORAGE

Store Zanaflex at 25°C (77°F); excursions permitted to 15-30°C (59-86°F)  Dispense in containers with child resistant closure.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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